Wednesday, January 25, 2012

Stem cell eye remedy 'seems safe'

Early results from the world's first human trial using embryonic stem cells to treat diseases of the eye suggest the method is safe, say researchers.

US firm Advanced Cell Technology told The Lancet how two patients who had received the retinal implants were doing well, four months on.

Trials of the same technique have now started at London's Moorfields Eye Hospital.

But experts say it will be years before these treatments are proven.

The aim of these first human studies is to establish that the treatment is safe to use.

The treatment takes healthy immature cells from a human embryo, which are then manipulated to grow into the cells that line the back of the eye - the retina.

Experts hope that by injecting these cells into a diseased eye, they will be able to restore vision for people with currently incurable conditions such as Stargardt's disease - one of the main causes of blindness in young people.

Advanced Cell Technology, along with the Jules Stein Eye Institute at the University of California, Los Angeles, are reporting their first experiences with this treatment in human trials.

Continue reading the main story

?Start Quote

This is a significant moment because there has been so much expectation about human embryonic stem cells ?

End Quote Fergus Walsh BBC Medical Correspondent

The study involved one elderly patient in her 70s with dry age-related macular degeneration - the leading cause of blindness in the developed world - and another female patient in her 50s with Stargardt's disease.

Both had very poor vision and were registered blind.

Each patient was given an injection containing 50,000 of the retinal pigment epithelium cells into one of their diseased eyes.

After surgery, structural evidence confirmed the cells had attached to the eye's membrane as hoped, and continued to survive throughout the next 16 weeks of the study.

Furthermore, the procedure appeared to be safe, causing no signs of rejection or abnormal cell growth.

Although this study is not designed to see if the procedure actually works, the researchers say their results do suggest that their patients' vision has improved slightly.

But they say it is still too soon to make any firm conclusions and that many more years of investigation will be needed to confirm that the treatment is both safe and effective.

They told The Lancet: "The ultimate therapeutic goal will be to treat patients earlier in the disease processes, potentially increasing the likelihood of photoreceptor and central visual rescue."

But even if this does become possible, such treatments would face stiff opposition by critics who say it is ethically wrong to use human embryonic tissue.

Dr Dusko Ilic, Senior Lecturer in Stem Cell Science at Kings College London, said that these early findings did not necessarily hint towards a viable treatment.

"We should keep in mind that people are not rats.

"The number one priority of initial clinical trial is always patient safety. If everyone expects that the blind patients will see after being treated with human embryonic stem cell-derived retinal pigment epithelium, even if the treatment ends up being safe (which is what Advanced Cell Technology are trying to determine in this trial), they risk being unnecessarily disappointed."

UK stem cell expert Chris Mason added: "We do not have a complete answer yet. But it is a valuable next step."

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/health-16687974

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Tuesday, January 24, 2012

Yemeni president departs, en route to US

Yemeni President Ali Abdullah Saleh left his battered nation Sunday on his way to the U.S. for medical treatment after passing power to his deputy and asking for forgiveness for any "shortcomings" during his 33-year rein.

But in a sign that Saleh's role as Yemen's top power broker is likely far from over, he said he would return to Yemen before the official power transfer next month to serve as the head of his ruling party.

Saleh's departure marks a small achievement in the months of diplomatic efforts by the U.S. and Yemen's powerful Gulf neighbors to ease the nearly year-old political crisis in the Arab world's poorest country. An active al-Qaida branch there has taken advantage of the turmoil, stepping up operations and seizing territory.

After months of diplomatic pressure and mass protests calling for his ouster, Saleh signed a deal in November to transfer authority to his vice president in exchange for immunity from prosecution. Still, Saleh continued to exercise power behind the scenes, sparking accusations he sought to scuttle the deal and cling to power.

His departure could help the deal go forward.

Presidential spokesman Ahmed al-Soufi told The Associated Press that Saleh left Yemen's capital Sanaa late Sunday on a plane headed for the Gulf sultanate of Oman. He did not say how long Saleh would remain there, but added that he would make "another stop before heading to the United States of America."

A senior administration official said Ali Abdullah Saleh would travel to New York this week, and probably stay in the U.S. until no later than the end of February. U.S. officials believe Saleh's exit from Yemen could lower the risk of disruptions in the lead-up to presidential elections planned there on Feb. 21.

The Obama administration faced a dilemma in deciding whether to let Saleh enter the U.S. after he requested a visa last month. It has long seen getting Saleh out of Yemen as an important step in ensuring the power transfer goes forward.

But some in the administration worried that welcoming Saleh would spark charges from the Arab world that the U.S. was harboring an autocrat responsible for deadly crackdowns on protesters.

To protect against this, the administration has sought assurances that Saleh will not seek to remain in the U.S.

An official close to Saleh said Sunday the president would undergo medical exams in Oman before heading to the U.S. The U.S. has forbidden him from any political activity in the U.S., the official said, speaking on condition of anonymity because he was not authorize to disclose diplomatic talks.

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Saleh is likely seeking treatment for injuries sustained in a blast in his palace mosque last June 3 that left him badly burned. After the attack, Saleh traveled to Saudi Arabia for treatment, leaving many to suspect his power was waning. A few months later, however, he made a surprise return to Yemen and resumed his post.

Under the power transfer deal signed in November, Vice President Abed Rabbo Mansour Hadi is to be rubber-stamped as the country's new leader in presidential elections. The political parties that signed the deal agreed not to nominate any other candidates.

In a farewell speech Friday reported by Yemeni state media, Saleh said he was passing his powers to Hadi, whom he promoted to the rank of marshal.

Saleh portrayed himself as a patriot who "gave his life in the service of the nation," called for reconciliation and apologized for any mistakes.

"I ask for forgiveness from all sons of the nation, women and men, for any shortcomings during my 33 years in office," Saleh said according to Yemen's state news agency.

He also called on Yemen's youth, who have spearheaded the mass protests calling for his ouster and often faced deadly crackdowns by Saleh's security forces, to go home.

"I feel for you and call on you to return to your homes and turn a new page with a new leadership," he said.

Yemen expert Gregory Johnsen of Princeton University said Saleh's departure could help the power transfer deal progress, though it will do little to address protesters' demands for a fundamental change of how politics in Yemen works.

Throughout his rule, Saleh has put close members of his family and tribe in charge of key state institutions and security forces, Johnsen said. Leaving that network intact could allow Saleh to continue to shape events in Yemen, even without the title of president.

"I don't think we have seen the last of President Saleh," Johnsen said.

Inspired by popular uprisings elsewhere in the Arab world, Yemenis took to the streets nearly a year ago to demand Saleh's ouster and call for democratic reforms. Saleh's security forces have met them with often deadly crackdowns, killing more than 200 protesters. Many others have been killed in violent clashes between armed groups that support the protesters and security forces.

Al-Qaida's active Yemeni branch has also taken advantage of the security collapse to seize territory in the country's south, even taking control of a town 100 miles from the capital Sanaa earlier this month.

The protests have continued despite the power transfer deal, which many say falls far short of their demands. They also reject the immunity clause, saying they want to see Saleh tried for his alleged role in the protester deaths.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/46091792/ns/world_news-mideast_n_africa/

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Turkey warns Iraqi PM over sectarian conflict (Reuters)

ANKARA (Reuters) ? Turkish Prime Minister Tayyip Erdogan warned his Iraqi counterpart, Nuri al-Maliki, on Tuesday that Ankara would not remain silent if he pursued a sectarian conflict in his country.

A war of words between the two neighbors has added to heightened regional tension. Turkey fears Iraq is heading toward a full-scale sectarian war while Baghdad has accused Ankara of meddling.

"Esteemed Maliki should know this - if you start a period of conflict in Iraq within a sectarian struggle, it will be impossible for us to remain silent," Erdogan told his AK Party parliamentary group in the Turkish capital.

Maliki's office responded with a statement again criticizing Turkey's "interference" in Iraq's affairs.

"This is not acceptable in the dealings between officials of different states and especially from heads of state," Maliki's office said. "Mr Erdogan has to be more careful in handling the usual protocols in international relations."

Fears of renewed sectarian conflict in Iraq have increased since U.S. troops withdrew in December and Maliki's Shi'ite-led government sought the arrest of a Sunni vice president on accusations he ran death squads.

Maliki's government denies it has a sectarian agenda, but the arrest warrant threatens to wreck a fragile ruling coalition that led to Sunni and Kurdish groups joining Maliki's cabinet.

DIPLOMATIC ROLE

Iraq summoned the Turkish ambassador in Baghdad last week to complain about comments by some Turkish officials it said amounted to meddling in its internal affairs.

While Iraq did not specify what Turkish remarks they were angry about, the complaint appeared to stem from comments this month by Erdogan, who said a Sunni-Shi'ite conflict in Iraq, if unleashed, could engulf the entire Islamic world.

Mainly Sunni but officially secular Turkey has sought to play a bigger diplomatic role in the Middle East, backed up by its growing might as the world's 16th biggest economy.

But while Ankara insists it maintains its official "zero problems with the neighbors" foreign policy, its support for Syrian demonstrators has drawn it into tensions with Iran, one of the main backers of the Damascus government.

Analysts say Turkey has heavily courted Sunni and Kurdish political blocs in Iraq in recent years while Iraq's Shi'ite parties remain closer to Shi'ite Iran.

In an interview with al-Hurra television this month, Maliki said: "Turkey is unfortunately playing a role which may lead to disaster and civil war in the region."

Tuesday, Erdogan described Maliki's comments about Turkey meddling in Iraq's affairs as "unfortunate" and "ugly."

"That Turkey is backing or is against a particular ethnic group or sect, whether in Syria or Iraq or in any other country in the region, is out of the question," Erdogan said.

"We see every problem in our region from a position of peace, stability and loyalty."

At least two rockets were fired at the Turkish embassy in Baghdad last week, Iraqi and Turkish sources said, prompting condemnation from Ankara which said it expected Iraq to take steps to provide security for Turkey's diplomatic missions.

Iraq is now Turkey's second biggest export market after Germany, with trade volume between the two reaching nearly $12 billion in 2011, Turkey's economy minister said during a visit to northern Iraq last week.

More than half of that trade is with Kurdistan, which puts the region in Turkey's top-10 trading partners.

(Writing by Jonathon Burch; Editing by Alison Williams and Robert Woodward)

Source: http://us.rd.yahoo.com/dailynews/rss/iraq/*http%3A//news.yahoo.com/s/nm/20120124/wl_nm/us_turkey_iraq

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Monday, January 23, 2012

Mexico authorities unravel child trafficking ring (AP)

ZAPOPAN, Mexico ? The Irish couples ensnared in an apparent illegal adoption ring in western Mexico thought they were involved in a legal process and are devastated by allegations organizers were trafficking in children, the families said Monday.

"All the families have valid declarations to adopt from Mexico as issued by the Adoption Authority of Ireland," they said in a statement, which was read over the phone to The Associated Press by their lawyer in Mexico, Carlos Montoya.

Prosecutors in Mexico contend the traffickers tricked destitute young Mexican women trying to earn more for their children and childless Irish couples desperate to become parents.

For 15-year-old Karla Zepeda, the story began in August when a woman came to her dusty neighborhood of cinderblock homes and dirt roads looking for babies to photograph for an anti-abortion ad campaign.

Zepeda told the AP that the woman, Guadalupe Bosquez, asked to use her 9-month-old daughter Camila in a two-week photo shoot for $755 ($10,000 pesos), a small fortune for a teen mother who earns $180 a month at a sandwich stand and shares a cramped, one-story house with her disabled mother, stepfather, and three brothers.

Bosquez later returned with another woman, Silvia Soto, and gave her half the money as they picked the child up. She got the rest two weeks later when they brought Camila home.

"They showed me a poster that showed my girl with other babies and said 'No To Abortion, Yes To Life,'" said Zepeda, a petite teenager cleaning her house to loud norteno music. "I thought it was legal because everything seemed very normal."

Before long, the message spread to her neighbors. Seven other women, most between the ages of 15 and 22, agreed to let their babies be part of the ad campaign. Some already had several children. Some were single mothers. Two of them didn't know how to read or write. Five of them told they AP that they did not even have birth certificates for their babies when they came across Bosquez and Soto.

One said she needed money to pay for her child's medical care. All deny agreeing to give their children up for adoption.

But instead of just posing for photographs, Jalisco state investigators say Camila and other babies were left for weeks at a time in the care of Irish couples who had come to Mexico thinking they were adopting the children.

Camila and nine other children have been turned over to state officials who suspect they were being groomed for illegal adoptions. And authorities hint that far more children could be involved: Lead investigator Blanca Barron told reporters the ring may have been operating for 20 years, though she gave no details. Prosecutors also say four of the children show signs of sexual abuse, though they didn't say how or by whom.

Nine people have been detained, including Bosquez and Soto, but no one has yet been charged.

At least 15 Irish citizens have been questioned, the Jalisco state attorney general's office said, but officials have not released their names and their lawyer says all have returned to Ireland after spending weeks or months in Ajijic, a town of cobblestone streets and gated communities 37 miles (60 kilometers) away, trying to meet requirements for adopting a child. None was detained.

In their statement, the Irish couples said they would not comment further because of the ongoing investigation.

The Mexican mothers say that Bosquez and Soto persuaded three of them to register their children as single mothers so they could participate in the anti-abortion campaign, even though they live with the children's fathers.

Children's rights activists say that also could have made it easier to release the child for adoption: only the mother's signature would be needed.

The mothers were assured that the babies were being taken care of by several nannies and checked by doctors. The children often returned home wearing new clothes.

Some of the mothers said they began having second thoughts. But when they declined to send their children back, they say, Bosquez and Soto insisted they would have to pay for the strollers, car seats, diaper bags and everything else they had bought for the babies.

"We're going through a nightmare," said Fernanda Montes, an 18-year-old housewife who said she took part to pay a $670 hospital bill from the birth of her 3-month-old. "How could we have trusted someone so evil?"

The plan began to unravel on Jan. 9, when local police detained 21-year-old Laura Carranza and accused her of trying to sell her 2-year-old daughter.

Investigators said Carranza denied that allegation, but acknowledged she was "renting" her 8-month-old son. She then led authorities to Bosquez and Soto.

Both are now being held on suspicion they ran the alleged anti-abortion ad campaign as a front for an illegal adoption ring. It was not clear if they have attorneys and they have not yet been brought before a judge to say if they accept or reject the allegations.

Carranza is also being held, as is Karla's mother, Cecilia Velazquez, who hasn't worked since she lost both legs in a traffic accident in 2010. Karla says her mother's only fault was agreeing to the ad campaign.

Seven of the mothers interviewed told the AP that the children had most recently been picked up by Bosquez and Soto between Dec. 27 and Dec. 30 for an alleged photo shoot. They returned the babies on Jan. 9 and 10, saying "there had been problems." The mothers said they didn't notice anything wrong with the babies or any signs of abuse.

Then state police investigators showed up at their homes and drove them and their children to the police department for questioning. The babies were taken from them and put into state protective custody. The women complained that only four of them have been allowed to see their babies since, and only once.

A statement from Jalisco state prosecutors' said authorities seized Carranza's two children from her and the other seven while they were with the Irish couples. Prosecutors didn't respond to requests by the AP to clarify the discrepancy.

Residents of Ajijic, a town on the shore of Lake Chapala favored by American and Canadian retirees, say Irish citizens looking to adopt Mexican children began appearing there at least four years ago.

Jalisco state prosecutors' spokesman Lino Gonzalez said none of the Irish had been charged with a crime.

Even if they had adopted the children, Ireland might not have accepted them because the adoptions were handled privately, said Frances FitzGerald, Ireland's minister for children.

"Obviously, for any couple caught up in this, it's a nightmare scenario," she said.

"What you can't have in Mexico is people going to local agencies or individuals doing private adoptions because when they come back, there is going to be a difficulty."

Prosecutors say they have been trying without success to reach the attorneys who were handling the adoption paperwork in the neighboring state of Colima.

Custody release statements signed by all of the mothers carry the logo of Lopez y Lopez Asociados, a firm owned by Carlos Lopez Valenzuela and his son, Carlos Lopez Castellanos. Authorities raided their home last week.

The release statements were shown to the AP by a local advocate for missing and stolen children, Juan Manuel Estrada of Fundacion FIND, who said they had been leaked to him by a state official. He said Lopez Valenzuela had separately sent him a lengthy statement by email declaring that he too may have been duped in the case and denying wrongdoing.

Prosecutors wouldn't confirm the authenticity of his statement to Fundacion FIND, but it mirrors the stories of seven mothers who were interviewed by the AP.

Lopez didn't respond to emailed interview requests from the AP.

The Irish couples told authorities they found Lopez Valenzuela through a website advertising his services, according to their lawyer, Carlos Montoya.

He said they were charged $6,000 for the search for a baby, $13,600 to gain final custody and $5,000 in legal fees, as well as the biological mother's supposed prenatal care, hospital care and nanny services.

The babies stayed with the couples in Ajijic for weeks at a time. Several of the couples had adopted Mexican children in the past with Lopez Valenzuela and hadn't had any problems, he said.

"They are innocent people who were swindled by the lawyer managing the adoptions," he said.

They all returned to Ireland last week on his advice, he said.

___

Associated Press writer Shawn Pogatchnik in Dublin contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/mexico/*http%3A//news.yahoo.com/s/ap/20120124/ap_on_re_la_am_ca/lt_mexico_child_trafficking

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Sonnen vs. Bisping is for title shot, but Chael says Silva will never fight him

Dana White released his first video blog for the card on FX today. One interesting scene includes the UFC president dealing with the withdrawal of Mark Munoz from the UFC on Fox 2 card. White is getting ready to release news of the new Chael Sonnen-Michael Bising fight and says the winner will get a title shot against the currently sidelined UFC middleweight champ Anderson Silva.

White must know something Sonnen doesn't because the outspoken contender sounds pretty sure he'll never face Silva.

"I'm not going to fight Anderson either way. They can say whatever they want. Anderson is never going to do that fight," Sonnen told "The MMA Insiders" show last week on Las Vegas' ESPN1100/98.9 FM. "I hope he's healthy and has a good life, but I'm not buying into this mythical world that Anderson is going to some day sign a contract to fight me."

During today's UFC on Fox 2 conference call, Sonnen reiterated his theory and said Silva turned down the fight to their boss' face.

"He even said no to (UFC executive) Lorenzo Fertitta's face. Face-to-face, not over the phone ? Lorenzo brought him out, sat him down, and said, 'This is the fight we want.' And Anderson said no," said Sonnen.

Sonnen knows management isn't pleased and questions the severity of Silva's back and shoulder injuries.

"They're not happy about it. The message to Anderson was this ' Chael is the opponent for you. You can fight him or you can't fight nobody. He elected to fight nobody,'" said Sonnen. "Dan Henderson said it perfectly, if the right opponent comes up, all of Anderson's injuries will go away."

Silva's next opponent will be known next Saturday night. A date and location is completely up in the air until Silva announces when he can officially return.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/sonnen-vs-bisping-title-shot-chael-says-silva-231128840.html

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Sunday, January 22, 2012

iVoices On the Issues: Gay Marriage

iVoice Stephanie Stearns Dulli gets fired up about the subject of gay rights and longs for the day when Democrats and Republicans agree to give gay people the same rights as straight men and women.

Source: http://www.ivillage.com/ivoices-issues-gay-marriage/1-h-420780?dst=iv%3AiVillage%3Aivoices-issues-gay-marriage-420780

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